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''Clostridium sordellii'' is a rare anaerobic, gram-positive, spore-forming rod with peritrichous flagella that is capable of causing pneumonia, endocarditis, arthritis, peritonitis, and myonecrosis. ''C. sordellii'' bacteremia and sepsis occur rarely. Most cases of sepsis from ''C. sordellii'' occur in patients with underlying conditions. Severe toxic shock syndrome among previously healthy persons has been described in a small number of ''C. sordellii'' cases, most often associated with gynecologic infections in women and infection of the umbilical stump in newborns. It has also been described in post-partum females, medically induced abortions, injection drug users and trauma cases.〔M. J. Aldape, A. E. Bryant, D. L. Stevens; Clostridium sordellii Infection: Epidemiology, Clinical Findings, and Current Perspectives on Diagnosis and Treatment; Clinical Infectious Diseases 2006; 43:1436-46〕 So far, all documented post-partum females who contracted C. sordellii septicaemia have died, and all but one woman who contracted the bacterium post-abortion have died . The source of the bacteria has not been determined but it has been documented that about 0.5% to 10% of healthy women are lengthened vaginal carriage of C. sordellii.〔Miech RP. Pathophysiology of mifepristone-induced septic shock due to Clostridium sordellii. Ann Pharmacother 2005; 39:1483-8〕 There are several clinical features which are unique to C. sordellii: marked leukocytosis (leukaemoid reaction), refractory hypotension, severe tachycardia, haemoconcentration, persistent apyrexia and profound capillary leak syndrome (see entry for ''Clostridium novyi'' alpha-toxin for details of mechanism.) In terms of management, there is no hard and fast rule as with most bacterial pathogens but past data reveals C. sordellii susceptibility to beta-lactams, clindamycin, tetracycline and chloramphenicol but resistant to aminoglycosides and sulphonamides. 〔Nakamura S, Yamakawa K, Nishida S. Antibacterial susceptibility of Clostridium sordellii strains. Zentralbl Bakteriol Mikrobiol Hyg () 1986; 261:345-9.〕 Pregnancy-associated infections - Toxic Shock Syndrome Also associated with a pediatric case where patient presented with a broken arm and was pronounced dead due to infection of ''C. sordellii'' three days later. == References == 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Clostridium sordellii」の詳細全文を読む スポンサード リンク
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